|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We identified seven susceptibility loci outside the human leukocyte antigen region (9p24 near JAK2, 10q22 at ZMIZ1, 11q13 near PRDX5, 16p13 near SOCS1, 17q21 at STAT3, 19p13 near FUT2, and 22q11 at YDJC) shared between PS and CD with genome-wide significance (p < 5 × 10(-8)) and confirmed four already established PS and CD risk loci (IL23R, IL12B, REL, and TYK2).
|
22482804 |
2012 |
|
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We further show that overexpression of hsa-miR-4516 downregulates STAT3, p-STAT3, CDK6, and UBE2N proteins that are consistently upregulated in psoriasis and induces apoptosis in HaCaT cells.
|
24610393 |
2014 |
|
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We also found that IL-22 increases CD147 transcription in vitro and in vivo and that Stat3 binds directly to the CD147 promoter between positions -854 and -440, suggesting that CD147 expression is up-regulated in patients with psoriasis through Stat3 activation.
|
28272440 |
2017 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Using a preclinical model of psoriasis, we show that intradermal injection of APTstat3 tagged with a 9-arginine cell-penetrating peptide (APTstat3-9R) reduced disease progression and modulated psoriasis-related cytokine signaling through inhibition of STAT3 phosphorylation.
|
29949348 |
2018 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Together, our results reveal a novel regulatory mechanism of IL-22 expression by STAT1 through directly antagonizing STAT3, and the importance of the balance between STAT3 and STAT1 in IL-22 regulation and psoriasis pathogenesis.
|
29750958 |
2018 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Thus, targeting Stat3 may be potentially therapeutic in the treatment of psoriasis.
|
15592573 |
2005 |
|
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The level of STAT3 mRNA and pSTAT3 was higher, but let-7a expression was lower in the psoriasis group than the control group.
|
28494466 |
2017 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The IL-22-STAT3-Bcl-3 pathway may be important in the pathogenesis of psoriasis.
|
28901004 |
2018 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings indicated that the curative effects of CTS on psoriasis are accomplished mainly through modulating STAT3, which providing evidences to develop CTS as a potential therapeutic agent for patients with psoriasis.
|
29427477 |
2018 |
|
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3-Ser727 phosphorylation as a modulator of transcriptional activity.
|
23614738 |
2013 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Silencing the target gene STAT3 in psoriatic KCs with siRNA combined with ultrasonic irradiation and microbubbles would contribute to a significant innovation as a new clinical therapy for psoriasis.
|
30127220 |
2018 |
|
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Several mouse models of psoriasis including drug-induced models (topical application of imiquimod to the skin) and genetically engineered mice (constitutive activation of epidermal STAT3, epidermal deletion of JunB/c-Jun, and epidermal overexpression of Tie2) have been used to study the pathophysiology of the disease; however such models cannot fully recapitulate all molecular and cellular pathways occurring in human psoriasis.
|
28063039 |
2017 |
|
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Several common TFs that bind the promoters of the DEGs, including the well-known signal transducer and activator of transcription 1 (STAT1), STAT3, and nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) as well as ETS homologous factor (EHF), Fos-like antigen 1 (FOSL1), and Forkhead box C1 (FOXC1), which are rarely studied in psoriasis, were also identified.
|
30825251 |
2019 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Salidroside inhibits MAPK, NF-κB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation.
|
31495284 |
2019 |
|
Psoriasis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
rs744166GG in STAT3 and rs7574865TT in STAT4 had higher frequencies in the case than the control group, suggesting these 2 genotypes increase the susceptibility to psoriasis (p < 0.05).
|
28420002 |
2017 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Phosphorylation of STAT3 was also assessed in lesional skin of CTCL and psoriasis by immunohistochemistry.
|
22048239 |
2011 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our study suggests that Stat3 activation in keratinocytes may impact on LC activation in situ via IL-1α stimulation, at least in part, and that their presence may be essential for the pathogenesis of psoriasis through producing IL-23.
|
30514663 |
2019 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that miR-320b negatively regulates NHEK proliferation by targeting AKT3 to regulate the STAT3 and SAPK/JNK signaling pathways and might participate in the pathogenesis of psoriasis in Chinese Han populations. miR-320b may also be a novel diagnostic marker or therapeutic target for this disease.
|
30136020 |
2018 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our data suggest that systemic IL-23/STAT3 axis is responsible for enhanced airway inflammation during psoriasis.
|
27984001 |
2017 |
|
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
It was observed that 'psoriasis 1' downregulated the concentrations of TNF‑α, IFN‑γ, IL‑22, IL‑17C, IL‑1β and IL‑4, and upregulated the concentration of 25HVD3; furthermore, 'psoriasis 1' downregulated the expression levels of NF‑κB, phosphorylated (p)‑NF‑κB, IKK, p‑IKK, STAT3, p‑STAT3, STAT4 and p‑STAT4, and upregulated the expression level of VDR in TNF‑α‑induced HaCaT cells.
|
30015892 |
2018 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
It has been demonstrated that epidermal Stat3 activation is required for psoriasis development, since keratinocyte-specific Stat3 activation in a mouse model elicits a psoriasis-like phenotype, which is reversed by inhibition of Stat3 signaling.
|
23870655 |
2013 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results highlight the TRIM27 expression significantly increased by IL-6 and suggest a TRIM27/STAT3-dependent mechanism for regulation of inflammation and proliferation-associated development of psoriasis.
|
31747314 |
2020 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
CTD_human |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Herein, we reported that K17 could be modified through ubiquitination that controlled its stability and led to the phosphorylation and nuclear translocation of its interactor signal transducers and activators of transcription 3 (STAT3), which is a key regulator of cell proliferation in psoriasis.
|
29859926 |
2018 |
|
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Genistein suppresses psoriasis-related inflammation through a STAT3-NF-κB-dependent mechanism in keratinocytes.
|
30743203 |
2019 |